A FACILE SYNTHESIS OF NEW 2-AMINO-4H-PYRAN-3-CARBONITRILES BY A ONE-POT REACTION OF ????,????′-BIS(ARYLIDENE) CYCLOALKANONES AND MALONONITRILE IN THE PRESENCE OF K????CO????

A rapid and environmentally friendly method is developed for the synthesis of a series here of new substituted 2-amino-4H-pyran-3-carbonitriles through a one-pot condensation of malononitrile and ????,????-bis(arylidene) cycloalkanones in ethanol by using K2CO3 as a catalyst.Short experimental reaction times, excellent yields, no need to use cum

The purpose of this study is to distinguish the Greek borrowings in Albanian language and to define their role in the layers of the Albanian lexis.Even though Albanian is an Indo-European language, this fact does not mean that its entire lexical fund stems from its mother language Illyrian.The contacts korpskaft and the relations with the other nat

Background: Historically, health facilities in sub-Saharan Africa echofix spring reverb have mainly managed acute, infectious diseases.Few data exist for the preparedness of African health facilities to handle the growing epidemic of chronic, non-communicable diseases (NCDs).We assessed the burden of NCDs in health facilities in northwestern Tanzan

Objectives Hypoxia is a physiological state characterized by reduced oxygen levels in organs and tissues.It is a common clinicopathological process and a major cause of health problems in highland areas.Heart rate variability (HRV) is a measure of the balance in autonomic innervation to the heart.It provides valuable information on the regulation o

Abstract The emergence of drug resistance continues to be a major hurdle towards improving patient outcomes for the treatment of Multiple Myeloma.MTI-101 is a first-in-class peptidomimetic that binds a CD44/ITGA4 containing complex and triggers necrotic cell death in multiple myeloma cell lines.In this report, we show that acquisition of resistance